Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs.
Identifieur interne : 001230 ( Main/Exploration ); précédent : 001229; suivant : 001231Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs.
Auteurs : Jodi Mcgill [États-Unis] ; Nico Van Rooijen ; Kevin L. LeggeSource :
- The Journal of experimental medicine [ 1540-9538 ] ; 2008.
Descripteurs français
- KwdFr :
- Animaux, Antigènes d'histocompatibilité de classe I (immunologie), Communication cellulaire (immunologie), Femelle, Infections à Orthomyxoviridae (immunologie), Lymphocytes T CD8+ (immunologie), Lymphocytes T CD8+ (virologie), Mouvement cellulaire (immunologie), Mâle, Peptides (immunologie), Poumon (immunologie), Poumon (virologie), Protéines virales (immunologie), Souris, Souris de lignée BALB C, Souris transgéniques, Sous-type H2N2 du virus de la grippe A (immunologie).
- MESH :
- immunologie : Antigènes d'histocompatibilité de classe I, Communication cellulaire, Infections à Orthomyxoviridae, Lymphocytes T CD8+, Mouvement cellulaire, Peptides, Poumon, Protéines virales, Sous-type H2N2 du virus de la grippe A.
- virologie : Lymphocytes T CD8+, Poumon.
- Animaux, Femelle, Mâle, Souris, Souris de lignée BALB C, Souris transgéniques.
English descriptors
- KwdEn :
- Animals, CD8 Antigens (immunology), CD8-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (virology), Cell Communication (immunology), Cell Movement (immunology), Female, Histocompatibility Antigens Class I (immunology), Influenza A Virus, H2N2 Subtype (immunology), Lung (immunology), Lung (virology), Male, Mice, Mice, Inbred BALB C, Mice, Transgenic, Orthomyxoviridae Infections (immunology), Peptides (immunology), Viral Proteins (immunology).
- MESH :
- chemical , immunology : CD8 Antigens, Histocompatibility Antigens Class I, Peptides, Viral Proteins.
- immunology : CD8-Positive T-Lymphocytes, Cell Communication, Cell Movement, Influenza A Virus, H2N2 Subtype, Lung, Orthomyxoviridae Infections.
- virology : CD8-Positive T-Lymphocytes, Lung.
- Animals, Female, Male, Mice, Mice, Inbred BALB C, Mice, Transgenic.
Abstract
Influenza infections induce a rapid, but transient, dendritic cell (DC) migration from the lungs to the lymph nodes (LNs) that is followed by substantial recruitment of DCs into the lungs without subsequent migration to the LNs. Given that peripheral DCs are primarily thought to be involved in the initiation of adaptive immunity after migration into lymphoid tissues, what role these newly lung-recruited DCs play in influenza virus immunity is unclear. In this study, we demonstrate that loss of non-LN migratory pulmonary DC subsets increases mortality, sustains higher viral titers, and impairs pulmonary CD8 T cell responses. Reconstitution of the lungs with pulmonary plasmacytoid DCs, CD8+ DCs, or interstitial DCs restores CD8 T cell responses in a cell contact-, major histocompatability complex I-, and influenza peptide-dependent manner. Thus, after their initial activation in the LN, protective influenza-specific CD8 T cell responses require additional antigen-dependent interactions, specifically with DCs in the lungs.
DOI: 10.1084/jem.20080314
PubMed: 18591411
Affiliations:
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Given that peripheral DCs are primarily thought to be involved in the initiation of adaptive immunity after migration into lymphoid tissues, what role these newly lung-recruited DCs play in influenza virus immunity is unclear. In this study, we demonstrate that loss of non-LN migratory pulmonary DC subsets increases mortality, sustains higher viral titers, and impairs pulmonary CD8 T cell responses. Reconstitution of the lungs with pulmonary plasmacytoid DCs, CD8+ DCs, or interstitial DCs restores CD8 T cell responses in a cell contact-, major histocompatability complex I-, and influenza peptide-dependent manner. Thus, after their initial activation in the LN, protective influenza-specific CD8 T cell responses require additional antigen-dependent interactions, specifically with DCs in the lungs.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Iowa</li></region><settlement><li>Iowa City</li></settlement><orgName><li>Université de l'Iowa</li></orgName></list><tree><noCountry><name sortKey="Legge, Kevin L" sort="Legge, Kevin L" uniqKey="Legge K" first="Kevin L" last="Legge">Kevin L. Legge</name><name sortKey="Van Rooijen, Nico" sort="Van Rooijen, Nico" uniqKey="Van Rooijen N" first="Nico" last="Van Rooijen">Nico Van Rooijen</name></noCountry><country name="États-Unis"><region name="Iowa"><name sortKey="Mcgill, Jodi" sort="Mcgill, Jodi" uniqKey="Mcgill J" first="Jodi" last="Mcgill">Jodi Mcgill</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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